Roswell Park

Elm & Carlton St.
Buffalo, NY 14263

HIPEC at Roswell Park

CS/HIPEC for Advanced Abdominal Disease

Peritoneal carcinomatosis (PC) affects approximately 10% to 30% of patients with colorectal cancer and represents a challenging treatment issue for these patients. Response to modern oxaliplatin- and ironotecan-based systemic chemotherapy remains disappointing and median overall survival for colorectal PC is 12.7 months with a 5-year overall survival of ≤ 4% (Franko, et al. JCO 2011).

A complex procedure, CS/HIPEC can be done safely and offers many patients an effective therapeutic option.


After meticulous cytoreductive surgery to debulk the tumor(s), the peritoneal cavity is bathed with heated, high-dose chemotherapy. The procedure entails:

  • Removal of gross tumor through a combination of visceral resection and selective peritonectomies only for involved surfaces (no “peritoneal stripping”)
  • Chemotherapy dosing at 3 to 4 times the maximum tolerated dose for systemic therapy (taking advantage of the plasma/peritoneal barrier)
  • Mitotycin C is used most commonly
  • Hyperthermia—42˚C for 90 minutes—increases drug uptake by tumor cells and may be directly tumoricidal
  • At procedure’s end, all chemotherapy is removed Duration of hospital stay averages 10 to 14 days


  1. Direct access to the tumor
  2. Minimizes tumor burden
  3. Maximizes chemotherapy dose (taking advantage of the plasma/peritoneal barrier)
  4. Achieves true fever range hyperthermia to increase response rates
  5. Does not preclude other therapies such as systemic chemotherapy

As a multidisciplinary comprehensive cancer center, we call upon highly-skilled professionals from all areas of cancer care, dedicated to treating the whole patient, not just their cancer. We work as a team along with the patient’s primary physician or community-based oncologist to provide optimal care delivered with compassion and respect.

Additional Resources

Mesothelioma - terminology

CS/HIPEC for mesothelioma treatment

Bathing the abdomen in heated chemotherapy as part of surgery improves survival. Most people think of the lungs when they think of mesothelioma, a cancer caused definitively by exposure to asbestos fibers that oncologists typically treat with systemic chemotherapy....