The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is a public academic health science center in San Antonio, Texas. It is part of the University of Texas System.

UT Health San Antonio is the largest health sciences university in South Texas. It is located in the South Texas Medical Center and serves San Antonio and all of the 50,000 square miles (130,000 km2) area of Central and South Texas. It extends to campuses in the Texas border communities of Laredo and the Lower Rio Grande Valley.

UT Health San Antonio is home to the Mays Cancer Center, which is in partnership with the MD Anderson Cancer Center and is a designated a National Cancer Institute Cancer Center. The Mays Cancer Center’s Institute for Drug Development (IDD) is internationally recognized for conducting one of the largest oncology Phase I clinical drug trials programs in the world. Fifteen of the cancer drugs most recently approved by the U.S. Food & Drug Administration underwent development or testing at the IDD.