At Mount Sinai, we have pioneered the use of a novel approach to treat abdominal cancers called hyperthermic intraperitoneal chemoperfusion (HIPEC). While cancers of the abdominal lining have been difficult to treat in the past with traditional surgery, HIPEC combines surgery with chemotherapy, revolutionizing how we treat these unique cancers. Responding to the lack of hospitals providing such a revolutionary treatment option, Mount Sinai established what is today one of the busiest HIPEC programs in the country. Faculty have performed more than 500 adult HIPEC procedures since the program’s creation in 2007, a number that will surely grow now that we are one of only two hospitals in Manhattan to offer pediatric HIPEC with a dedicated full-time faculty member specially trained in pediatric surgical oncology.
HIPEC delivers heated chemotherapy directly into the abdominal cavity, where it penetrates the diseased tissue directly. Because HIPEC allows the chemotherapy to go directly to the site of the cancer, you will not experience any of the side effects of intravenous chemotherapy. It also destroys undetected cancer cells after the tumor has been removed, preventing the formation of new tumors, so the cancer cannot recur. This combination procedure has improved outcomes significantly.
HIPEC works by using a combination of heat and chemotherapy. The procedure first removes all of the visible tumors using traditional surgery, followed by an internal bath of heated chemotherapeutic solution to kill any remaining cancer cells using cytoreductive surgery.
Mount Sinai runs one of the most experienced HIPEC programs in the country, having performed more than 500 adult HIPEC procedures since the program’s creation in 2007. As leaders in the use of this novel technique, you can trust that you are receiving the best treatment possible while in our care.
Conditions We Treat
We use HIPEC to treat tumors in the abdominal (peritoneal) lining that stem from colon, gastric, ovarian, and other cancers.
Schedule a consultation with one of our expert surgeons to find out if you are eligible for HIPEC, and if the procedure is right for you. Our surgical oncologists at Mount Sinai are on the forefront of this groundbreaking procedure and have the type of extensive experience you seek in your surgeon.
Schedule a conversation with a surgeon today!
A Patient’s Guide to HIPEC
What does HIPEC stand for and what does it mean?
HIPEC stands for Hyperthermic IntraPEritoneal Chemotherapy During HIPEC treatment, the chemotherapy solution is heated to 42-43 degrees Celsius (107-09 degrees Fahrenheit) and instilled into the abdomen for approximate y 90 minutes. The term “intraperitoneal” means that the treatment is delivered to the abdominal cavity. The term “hyperthermic chemotherapy” simply means that the solution containing chemotherapy is heated to a temperature that is greater than normal body temperature. ABOUT Normal Body temperature is 37 degrees Celsius, or 98.6 degrees Fahrenheit. HIPEC HIPEC is essentially a chemotherapy “bath” that delivers heated chemotherapy directly into the abdominal cavity, where it penetrates the diseased tissue directly. This targeted contact of the heated drug softens the tumor nodules, which increases absorption of the chemotherapy solution.
Because HIPEC allows the chemotherapy to be directly distributed to the site, the known side effects of chemotherapy that are normally administered intravenously are eliminated. Additionally, it destroys undetected cancer cells after the tumor has been removed, preventing them from forming into new tumors and causing a reoccurrence of cancer.
How does HIPEC work?
HIPEC uses a combination of heat and chemotherapy. The procedure is done by first removing all visible tumors. This is followed by an internal bath of heated chemotherapeutic solution to kill any remaining cancer cells. Before HIPEC is administered, the surgeon-using standard surgical methods-will remove all visible tumors that can be removed throughout the peritoneal cavity. This is known as cytoreductive surgery.
How does HIPEC differ from traditional chemotherapy?
Some types of cancers are very difficult to treat, particularly the ones located in the abdominal cavity. HIPEC experts say the heat makes the chemotherapy more powerful at killing these cancer cells.
What cancers does HIPEC treat?
HIPEC treats cancers in the abdominal (peritoneal) lining that stem from colon, gastric, ovarian and appendiceal cancers, as well as mesothelioma and pseudomyxoma peritonei.
What are the benefits of HIPEC?
HIPEC experts say the treatment is more effective at killing cancer cells. In addition, the procedure also improves drug absorption with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided. Through HIPEC surgery, doctors are able to remove any cancerous tissues and treat them aggressively while minimizing the negative effects of high doses of intravenous chemotherapy. This aspect of HIPEC helps to extend the patient’s life.
Who is a candidate for HIPEC?
It is best to discuss with your doctor if this procedure is right for you. Doctors at Mount Sinai have been on the forefront of this groundbreaking procedure, offering it to patients for several years.
During the HIPEC procedure, the surgeon will continuously circulate a heated sterile solution containing a chemotherapeutic agent throughout the peritoneal cavity, for a maximum of two hours. The HIPEC procedure is designed to attempt to kill any remaining cancer cells. The sterile solution will then be drained away and the surgical incision will be closed. The procedure also improves drug absorption and effect with minimal exposure to the rest of the body. In this way, the normal side effects of chemotherapy can be avoided. It is best to discuss with your doctor if this procedure is right for you. Doctors at Mount Sinai have been on the forefront of this groundbreaking procedure, offering it to patients for several years.