Roswell Park Comprehensive Cancer Center
Elm & Carlton St.
Buffalo, NY 14263

 

 

In the past, carcinomatosis was treated with systemic chemotherapy, with surgery for palliative purposes. More recently, cytoreduction, or surgical removal of all visible tumor nodules in the abdominal cavity, followed by hyperthermic intraperitoneal chemotherapy (HIPEC), has become an option. This procedure may be beneficial as part of the management of patients with cancers originating in the appendix such as pseudomyxoma peritoneii [also known as disseminated peritoneal adenomucinosis (DPAM), or peritoneal mucinous adenocarcinoma (PMCA)], gastrointestinal primary cancers such as colorectal cancer, and peritoneal mesothelioma. Both at RPCI and elsewhere, cytoreduction/HIPEC has had a meaningful impact on the survival rates of these patients. The increase in clinical interest and ongoing research has made patients and families more aware of this as a treatment option.

RPCI has a well-established cytoreduction/HIPEC program, with two surgeons providing consultation and surgical procedures. However, this procedure is not available at every center, given the required infrastructure, and expertise in surgical management and post-operative care. RPCI is the only center in Western New York offering cytoreduction/HIPEC. Also, not all patients are appropriate candidates for the procedure. We spend a great deal of time ensuring we have reviewed all of the patient’s information at a first visit and have a thorough discussion with the patient regarding risks and benefits.

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HIPEC at Roswell Park

HIPEC is an alternative and innovative method of delivering chemotherapy, which is commonly used to treat many types of cancer, to the body. Unlike traditional chemotherapy that is delivered intravenously, HIPEC delivers chemotherapy directly into the abdomen making it a good option for cancers that originated in or have spread to the abdominal cavity. How does HIPEC work? First, your surgeon removes any visible tumors from the abdomen. Next, HIPEC delivers heated chemotherapy directly inside the abdomen to help destroy any remaining cancer cells and very small tumors that cannot be seen by the surgeon. This is because the chemotherapy circulates inside the abdomen, allowing it to reach more places. The goal of HIPEC is to prevent these cells from growing into new tumors and causing

How does HIPEC work?

First, your surgeon removes any visible tumors from the abdomen. Next, HIPEC delivers heated chemotherapy directly inside the abdomen to help destroy any remaining cancer cells and very small tumors that cannot be seen by the surgeon. This is because the chemotherapy circulates inside the abdomen, allowing it to reach more places. The goal of HIPEC is to prevent these cells from growing into new tumors and causing First, your surgeon removes any visible tumors from the abdomen. Next, HIPEC delivers heated chemotherapy directly inside the abdomen to help destroy any remaining cancer cells and very small tumors that cannot be seen by the surgeon. This is because the chemotherapy circulates inside the abdomen, allowing it to reach more places. The goal of HIPEC is to prevent these cells from growing into new tumors and causing the cancer to return.

What are the benefits of HIPEC procedures?

  • HIPEC allows for a higher concentration of chemotherapy to be delivered into the abdomen more effectively and safer than standard chemotherapy, which is delivered intravenously.
  • This type of chemotherapy is best at killing cancer cells that are too small to be seen with the naked eye.
  • Chemotherapy delivered through HIPEC causes fewer side effects than intravenous chemotherapy. This is because the high concentrations of chemotherapy solution are unable to cross what is known as the peritoneal plasma barrier.
  • Experts say that pairing surgery and HIPEC together may be more beneficial than chemotherapy alone.

Am I a candidate for HIPEC?

Typical HIPEC patients are those with certain Stage IV abdominal cancers. Many are seeking an alternative to traditional chemotherapy or radiation therapy, as these options offer limited success treating advanced abdominal cancers. Patients also may have been told that no other treatment will work, but are still hoping to find a solution.